منابع مشابه
Targeting Autophagy Addiction in Cancer
Autophagy inhibition is a novel cancer therapeutic strategy in the early stages of clinical trial testing. The initial rationale for using autophagy inhibition was generated by research revealing that autophagy is upregulated in response to external stresses, including chemotherapy and radiotherapy. Combining autophagy inhibition with agents that induce autophagy as a pro-survival response may ...
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Tyrosine kinases play significant roles in tumor progression and therapy resistance. Inhibitors of tyrosine kinases are on the forefront of targeted therapy. For prostate cancer, tyrosine kinases play an additional role in the development of castration-resistant disease state, the most troubling aspect of prostate cancinogenesis which presently defies any effective treatment. Among the 30 or so...
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Autophagy is a highly regulated catabolic process involving lysosomal degradation of intracellular components, damaged organelles, misfolded proteins, and toxic aggregates, reducing oxidative stress and protecting cells from damage. The process is also induced in response to various conditions, including nutrient deprivation, metabolic stress, hypoxia, anticancer therapeutics, and radiation the...
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Macroautophagy (autophagy hereafter) captures and degrades intracellular proteins and organelles in lysosomes as a quality control mechanism and recycles their components to sustain survival in starvation. Cellular self-cannibalization by autophagy is thought to have a context-dependent role in cancer. Autophagy inactivation is destructive to normal tissues and can promote cancer initiation whi...
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Autophagy is a homeostatic process that degrades long-lived or damaged proteins and organelles. By recycling intracellular constituents, it is buffering metabolic stress under starvation conditions. The autophagy role in cancer remains unclear and complicated as it appears to be involved in tumorigenesis, cancer development and treatment outcome in different ways. Autophagy can act as both tumo...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2017
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc.2017.53